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As iron continues to build up in the body, complications happen more often

About 70%

of deaths in thalassemia major patients are due toheart complications and disease.

Despite improvements in care, iron overload in the heart is the leading cause of death among people with thalassemia major

Don’t forget your other organs!

Careful monitoring of liver and kidney function is important to prevent further damage to the organs. Talk to your doctor and ensure you are on an appropriate iron chelator at the right dosing level that doesn’t impact your kidneys or liver.

The only way to know if your iron chelator is working is to have your iron levels checked regularly

Iron chelation needs to be adjusted regularly or even switched depending on your iron level, weight, and tolerance to side effects

Thalassemia treatment guidelines support regular monitoring of serum ferritin, and MRI T2* of the heart and liver
ParameterTargetExpert panel recommendation
Serum ferritin<500 ng/mLMonthly
Cardiac MRI T2*20 milliseconds (ms) or higherYearly (Or every 6 months if your T2* is <10 ms)
Liver iron concentration (LIC)<3,000 µg/g dry weightYearly

Lowering serum ferritin and liver iron concentration are not enough. Reducing cardiac iron is the priority in thalassemia.

Appropriate chelation treatment maintains iron levels within recommended ranges.